The feasibility and benefits of lateral flow assay (LFA)-based antibody tests for detecting inadequate COVID-19 immunity.
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMJun 17 2024 In a recent study published in Science Advances, a group of researchers evaluated the feasibility and benefits of lateral flow assay -based antibody tests for detecting inadequate coronavirus disease 2019 immunity and informing booster vaccination decisions in a healthcare provider cohort.
With the emergence of Omicron subvariants, waning immunity raised concerns, yet booster uptake remains low. Factors such as vaccine hesitancy and side effects contribute to this. Further research is needed to validate the effectiveness of point-of-care tests in diverse populations and to optimize strategies for enhancing booster vaccine uptake.
Recombinant protein antigens were used in Enzyme-Linked Immunosorbent Assay assays to measure antibody responses. Multiplex surrogate neutralization assays evaluated Angiotensin-Converting Enzyme 2 blocking antibodies to SARS-CoV-2 variants. NV subjects showed a 62% decrease in ACE2-blocking antibodies and a 56% decrease in neutralizing activities, while IV subjects experienced a 33% reduction in ACE2-blocking antibodies and an insignificant change in neutralizing antibodies.
The oral fluid LFA test demonstrated good positive and negative agreement with live-virus neutralization assays, supporting its use in informing individuals about weak SARS-CoV-2 functional antibody responses.
Covid-19 Research ACE2 Antibodies Assay Blood Cell Coronavirus ELISA Enzyme Healthcare Immunity Immunoglobulin Omicron Protein Receptor Respiratory SARS SARS-Cov-2 Severe Acute Respiratory Severe Acute Respiratory Syndrome Spike Protein Syndrome T-Cell Vaccine Virus
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