ASH22 'Astonishing' results: Skip salvage chemo, go straight to HSCT
The results after 4 years of follow-up showed no differences in either leukemia-free survival or overall survival between patients who underwent additional chemotherapy with the remission-induction strategy and those who went straight to transplant, reported Johannes Schetelig, MD, MSc, from the Clinical Trials Unit at DKMS in Dresden, Germany.
He also gave details of the two treatment arms of the ASAP trial. The remission-inducing arm consisted of cytarabine twice daily on days 1-3 plus 10 mitoxantrone mg/mon days 3-5 and subsequent alloHCT. In the other group — disease control prior to sequential conditioning and alloHCT — watchful waiting was recommended, but low-dose cytarabine and single doses of mitoxantrone were permitted for disease control.
In addition, after a median follow-up from randomization of 37 months, there were no differences in either leukemia-free survival or overall survival out to 4 years after DFS at day 56.
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