Science, Space and Technology News 2024
Zebrafish can regenerate their spinal cords due to the survival and adaptability of injured neurons, offering potential insights for treating human spinal cord injuries. This new research highlights the importance of saving neurons from death, rather than relying only on stem cells, as a strategy for healing.
A new study from Washington University School of Medicine in St. Louis maps out a detailed atlas of all the cells involved — and how they work together — in regenerating the zebrafish spinal cord. In an unexpected finding, the researchers showed that survival and adaptability of the severed neurons themselves are required for full spinal cord regeneration.
When the long wiring of the spinal cord is crushed or severed in people and other mammals, it sets off a chain of toxicity events that kills the neurons and makes the spinal cord environment hostile against repair mechanisms. This neuronal toxicity could provide some explanation for the failure of attempts to harness stem cells to treat spinal cord injuries in people.
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