Olderadults who remain more active have a better qualityoflife, study finds Cambridge_Uni
Yerrakalva D, Hajna S, Wijndaele K, Dempsey PC, Westgate K, Wareham N, et al. Bidirectional associations of accelerometer-assessed physical activity and sedentary time with physical function among older English adults: the EPIC-Norfolk cohort study. Eur J Ageing [Internet]. 2022;19:1507–17. Available from:Yoshimura J, Tanimura C, Matsumoto H, Tokushima Y, Inoue K, Park D, et al. Relationship of physical activity to self-care agency and physical condition among older adults in a rural area.
Niederstrasser NG, Attridge N. Associations between pain and physical activity among older adults. PLoS One [Internet]. 2022;17. Available from:Pearce M, Garcia L, Abbas A, Strain T, Schuch FB, Golubic R, et al. Association between physical activity and risk of depression: a systematic review and meta-analysis. JAMA Psychiatry [Internet]. 2022;79:550–9. Available from:Falck RS, Davis JC, Liu-Ambrose T.
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Associations between DNA methylation and gene regulation depend on chromatin accessibility during transgenerational plasticity - BMC BiologyBackground Epigenetic processes are proposed to be a mechanism regulating gene expression during phenotypic plasticity. However, environmentally induced changes in DNA methylation exhibit little-to-no association with differential gene expression in metazoans at a transcriptome-wide level. It remains unexplored whether associations between environmentally induced differential methylation and expression are contingent upon other epigenomic processes such as chromatin accessibility. We quantified methylation and gene expression in larvae of the purple sea urchin Strongylocentrotus purpuratus exposed to different ecologically relevant conditions during gametogenesis (maternal conditioning) and modeled changes in gene expression and splicing resulting from maternal conditioning as functions of differential methylation, incorporating covariates for genomic features and chromatin accessibility. We detected significant interactions between differential methylation, chromatin accessibility, and genic feature type associated with differential expression and splicing. Results Differential gene body methylation had significantly stronger effects on expression among genes with poorly accessible transcriptional start sites while baseline transcript abundance influenced the direction of this effect. Transcriptional responses to maternal conditioning were 4–13 × more likely when accounting for interactions between methylation and chromatin accessibility, demonstrating that the relationship between differential methylation and gene regulation is partially explained by chromatin state. Conclusions DNA methylation likely possesses multiple associations with gene regulation during transgenerational plasticity in S. purpuratus and potentially other metazoans, but its effects are dependent on chromatin accessibility and underlying genic features.
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