A study published in BMCMedicine finds that regular glucosamine use is associated with a lower risk of all-cause dementia, Alzheimer’s disease, and vascular dementia. Further studies are recommended to confirm the findings.
Cox proportional hazard models were used to calculate the hazard ratios and 95% confidence intervals for the relationships between regular glucosamine use and all-cause dementia, AD, and vascular dementia. We tested the proportional hazards assumption by Schoenfeld residual tests [], and no violations of this assumption were identified. Two models were used. We only included sex and age in Model 1.
In order to evaluate potential effect modifiers, subgroup analyses based on sex , age , obesity , current smoking status , diabetes , hypertension , aspirin use , use of non-aspirin NSAIDs , use of vitamin supplementation , use of other non-vitamin supplementation andε4 carrier were performed.
We evaluated the robustness of our findings by a sequence of sensitivity analyses . Firstly, we conducted an analysis of competing risks which considered all-cause mortality as a competing event for dementia. Secondly, since individuals who took glucosamine were more likely to take chondroitin than those who did not, we conducted sensitivity analyses by removing chondroitin users.
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