Association of Benzodiazepines for Sleep Disorders With Drug Overdose Risk

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Association of Benzodiazepines for Sleep Disorders With Drug Overdose Risk
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Drug used for sleepdisorders is linked to higher risk of overdose in teens, youngadults RutgersU jamanetworkopen

codes were restricted to codes for initial encounters. We also separately examined overdoses recorded to involve benzodiazepines . Both outcomes capture primarily nonfatal overdose events; fatal overdoses were included if patients were brought to an ED or hospital.Patient-level variables were included to describe the study population and as confounders.

Propensity scores were estimated with logistic regression and applied using inverse probability of treatment weighting to estimate the adjusted cumulative incidence and HRs. The potential confounders and the factors associated with drug overdose were included in the propensity score model . Inverse probability of treatment weights were applied to the Cox proportional hazards regression model, and no other covariates were added.

As-treated and intention-to-treat cumulative incidences and HRs are presented. In ITT analyses, youths were followed up until overdose, 6 months, insurance disenrollment, or end of data , whichever came first. In as-treated analyses, youths were followed up until treatment discontinuation , overdose, 6 months, insurance disenrollment, or end of data, whichever came first. Individuals were analyzed based on initial treatment.

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