Dr Don Dizon highlights new data in gynecologic cancers from the 2024 ASCO Annual Meeting.
Professor of Medicine and Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York; Director, Pelvic Malignancies Program, Lifespan Cancer Institute, Providence, Rhode IslandServe as a director, officer, partner, employee, advisor, consultant, or trustee for: AstraZeneca; GlaxoSmithKline; Clovis; Pfizer
With nivolumab, the overall response rate was 14.3%. That included two partial responders among 15 people treated. That response rate with the combination went to 33%, including five complete responses in this population. Progression-free survival with single-agent nivolumab was 2 months, and overall survival was 17 months. With the combination, it was 6 months of progression-free survival and 24 months of overall survival.
Whether combination immunotherapeutic approaches are going to show an advantage in terms of surviving ovarian cancer is the next question that should be asked. Being very selective about who we want to further evaluate in terms of subgroups is also very important. . This ended up being the second trial that showed there was no benefit to postchemotherapy radiation plus chemotherapy consisting of carboplatin and paclitaxel. There was no survival advantage seen.
Malignant Ovarian Neoplasm Ovary Cancer Biologic Therapy Biologics Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Cervical Cancer Malignant Neoplasm Of The Cervix Endometrial Carcinoma Endometrial Cancer Carcinoma Of The Endometrium Cancer Of The Endometrium Chemotherapy Combination Chemotherapy Clinical Research Clinical Trials Clinical Studies
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