ASCO 2024: Key Insights Into Enhancing Treatment Efficacy and Managing Toxicity in Urothelial Carcinoma

Bladder Cancer News

ASCO 2024: Key Insights Into Enhancing Treatment Efficacy and Managing Toxicity in Urothelial Carcinoma
Malignant Bladder NeoplasmTransitional Cell CarcinomaUrothelial Carcinoma
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Scott T. Tagawa, MD, dives into highlights from ASCO 2024, including notable data on enfortumab vedotin and gemcitabine-cisplatin plus nivolumab.

Professor of Medicine & Urology, Co-Leader, Cancer Therapeutics Program, Meyer Cancer Center, Weill Cornell Medicine, NewYork-Presbyterian Medical Center, New York, NYReceived research grant from: Sanofi; Medivation; Astellas; Janssen; Amgen; Progenics; Dendreon; Lilly; Genentech; Newlink; BMS; Inovio; AstraZeneca

Received income in an amount equal to or greater than $250 from: Sanofi; Medivation; Astellas; Dandreon; Janssen; Genentech; Bayer; Endocyte; Eisai; Immunomedics; Karyopharm; AbbVieimproves response rates, whereas dose reductions and delays are effective for managing toxicity without affecting efficacy. Additional data on this agent from theoutperforms gemcitabine-cisplatin alone, especially in patients with lymph node–only disease.

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Malignant Bladder Neoplasm Transitional Cell Carcinoma Urothelial Carcinoma Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Toxicology Toxicity Poisoning Toxins Medical Conferences Professional Societies Fellowship Fellows Adverse Effects Side Effects Lymph Nodes Patient Safety

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ASCO 2024: Key Insights Into Enhancing Treatment Efficacy and Managing Toxicity in Urothelial CarcinomaASCO 2024: Key Insights Into Enhancing Treatment Efficacy and Managing Toxicity in Urothelial CarcinomaThis article summarizes key takeaways from the 2024 American Society of Clinical Oncology (ASCO) conference, focusing on advancements in the treatment of urothelial carcinoma. It highlights new data on enfortumab vedotin (EV) demonstrating improved response rates with higher initial doses while managing toxicity effectively. The article also explores the importance of personalized treatment strategies, including FGFR inhibitors and immune checkpoint inhibitors, and discusses emerging biomarkers and treatment approaches for this disease.
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