Aging may be less about specific 'aging genes' and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers.
Aging may be less about specific 'aging genes' and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers. A decline in the expression of long genes with age has been observed in a wide range of animals, from worms to humans, in various human cell and tissue types, and also in individuals with neurodegenerative disease.
The authors span four research groups from Spain, the Netherlands, Germany, and the United States, with each group arriving at the same conclusions using different methods. "For a long time, the aging field has been focused on genes associated with aging, but our explanation is that it is much more random -- it's a physical phenomenon related to the length of the genes and not to the specific genes involved or the function of those genes," says co-author Ander Izeta of the Biogipuzkoa Health Research Institute and Donostia University Hospital, Spain.
The authors speculate that damage to long genes could explain most of the features of aging because it is associated with known aging accelerants and because it can be mitigated with known anti-aging therapies, such as dietary restriction . In future studies, the researchers plan to further investigate the phenomenon's mechanism and evolutionary implications and to explore its relationship with neurodegeneration.Chicago
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