As the FDA evaluates ecstasy treatment for PTSD, questions mount about the evidence

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As the FDA evaluates ecstasy treatment for PTSD, questions mount about the evidence
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Clinical trials of MDMA have been promising, but concerns have emerged about the quality of the research. A June hearing scheduled by the Food and Drug Administration is likely to address them.

In a matter of months, the Food and Drug Administration is expected to decide whether the drug commonly known as ecstasy can be used as a treatment for post-traumatic stress disorder.

Casey Tylek, a participant in the Phase 3 trials, says he had no experience with the drug prior to the study. "Concerns have been raised by some that therapists encouraged favorable reports by patients and discouraged negative reports by patients including discouraging reports of substantial harms, potentially biasing the recording of benefits and harms," the report states.

But since then, a group of more than 70 clinicians, investigators and others involved in the Phase 3 MDMA trials have, a clinical psychologist in the Phase 3 trials, says she and her colleagues were shocked by how ICER described their work. Still, Mitchell acknowledges she doesn't have full insight into what was going on at each trial site on a given day.

It continues:"We cannot rule out the possibility that MAPS/Lykos manipulated clinical trial data to hide adverse events from regulatory agencies."

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