Drinking a no-or low-calorie non-nutritive sweetened beverage was no different from drinking water in terms of effect on 2-hour postprandial levels of glucose and hormones related to appetite or food intake.
suggesting that some non-nutritive sweeteners may have a minor effect on gut microbiome and glucose response."
First, the"sweet uncoupling hypothesis" proposes that low-calorie sweeteners affect sweet taste by separating sweet taste from calories."The body is confused, and then there is hormonal change. Our study shows that actually that's not true, and [NNS beverages] are similar to water." "We are not saying that anybody who is not taking low-calorie sweeteners should start taking [them]," he continued."What we are saying is somebody who is taking sugar-sweetened beverages and has a problem of taking excess calories, if you replace those calories with low-calorie sweetener, replacement of calories itself may be beneficial, and also they should not be concerned of any [acute] issues with a moderate amount of low-calorie sweeteners.
They identified 36 randomized and nonrandomized clinical trials of 472 predominantly healthy participants:12 trials : NNS consumed up to 15 minutes before oral glucose carbohydrate load Single NNS: ace-K, aspartame, cyclamate, saccharin, stevia, and sucralose
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