Are current COVID-19 vaccines in England effective against severe BA.4 and BA.5 Omicron sub-lineage infections? medrxivpreprint LSHTM imperialcollege COVID19 coronavirus covid Omicron infection vaccine
By Susha Cheriyedath, M.Sc.Sep 5 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* server, researchers investigated the vaccine efficacy of various coronavirus disease 2019 vaccines against the BA.2, BA.4, and BA.5 sub-lineages of the severe acute respiratory syndrome coronavirus 2 Omicron variant.
About the study In the present study, researchers in the UK estimated the effectiveness of the vaccines currently being administered in preventing hospitalization following BA.4 and BA.5 sub-lineage infections compared to BA.2 infections, with all three sub-lineages co-circulating. The team carried out a test-negative case-control study to estimate the VE against hospitalization in individuals 18 or older infected with BA.2, BA.4, or BA.5 sub-lineages. The VE was defined as the odds of vaccination in cases divided by the odds of vaccination in controls, subtracted from one. They also compared the incremental VE of individuals with a third or fourth dose with those who had their second dose 25 weeks ago and had waned immunity.
Results The researchers found no evidence of reduced effectiveness of the vaccines against hospitalization for the sub-lineages BA.4 and BA.5 as compared to BA.2. The incremental VE in individuals with third or fourth doses of vaccination was 56.8%, 59.9%, and 52.4% for BA.4, BA.5 and BA.2 respectively, which waned to 1.5%, 23.3%, and 9.8%, respectively, at 25 weeks or more since the second dose.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Study suggests loss of smell and brain inflammation are independent in COVID-19Study suggests loss of smell and brain inflammation are independent in COVID-19 biorxivpreprint institutpasteur Sorbonne_Univ_ unibern smell brain inflammation COVID19 coronavirus covid
Read more »
Flu and Covid jab programme starts ahead of 'winter wave of respiratory virus'Health care workers and care home residents are to start receiving Covid boosters and autumn flu jabs from Monday as the autumn vaccination programme gets under way.
Read more »
Covid: Millions invited for booster jabs from MondayHealth bosses predict a resurgence of the virus and flu during the autumn and winter.
Read more »
Covid pandemic has added almost 1.5 million people to the NHS waiting list in EnglandEven without the impact of Covid, the NHS in England would have expected to see a waiting list of around 5.3m people at the end of May 2022, health experts said
Read more »
New award to celebrate Oxford scientist Dr Ling Felce who died in crashDr Ling Felce, 'one of the brightest' scientists in her field, had been researching Covid immunity.
Read more »