Antibiotics are “miracle medicines,” but overuse in the first two years of life could be detrimental to protection against vaccine-preventable diseases.
“If anyone needed yet another reason why overprescription of antibiotics is not a good thing, this paper offers that reason,” says immunologist Bali Pulendran of Stanford University School of Medicine, who was not involved in the study.
in those whose prior immune memory for influenza had waned, Pulendran and colleagues reported in 2019.is the first to report an association between antibiotic use and compromised vaccine responses in children. Michael Pichichero, a pediatric infectious diseases specialist at the Rochester General Hospital Research Institute in New York, and colleagues collected blood samples taken from 560 children during routine visits with their pediatricians.
The researchers didn’t look at whether children in the study with diminished antibody levels were more likely to develop vaccine-preventable diseases. But there has been concern about To see what kinds of changes are occurring in the gut bacteria, Pichichero and colleagues are beginning a study with a new group of children. The researchers will collect stool samples along with blood draws and antibiotic use records. They’d like to follow the children past age 5, beyond the time kids receive another round of booster shots, to learn whether antibiotics also interfere with this next opportunity to develop antibodies.
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