Anti-CD20 HGG Linked to Serious Infection Risk in MS

Multiple Sclerosis News

Anti-CD20 HGG Linked to Serious Infection Risk in MS
Multiple SclerosisMSMS - Multiple Sclerosis
  • 📰 Medscape
  • ⏱ Reading Time:
  • 42 sec. here
  • 26 min. at publisher
  • 📊 Quality Score:
  • News: 104%
  • Publisher: 55%

Hypogammaglobulinemia is a known risk linked to B-cell–depleting therapies, but a real-world study has specified the risk and risk factors in multiple sclerosis.

Just under 10% of those who received either of the B-cell–depleting monoclonal antibody therapies developed HGG, the study showed. This correlated with the depletion of B cells and reductions in the immunoglobulin G and IgA.

Of 911 patients, 832 were treated with ocrelizumab and 179 with ofatumumab. The rates of HGG were 9.9% and 8.9%, respectively, a difference on univariate analysis that was not significant (Compared with patients on one of the two drugs who did not develop HGG, those who did were slightly older (48 vs 45 years;There was no difference between groups in mean body mass index, the presence of a progressive phenotype, or sex.

Alvarez noted that there were inconsistences regarding HGG risk from a series of small initial studies, but"as we look at these larger studies, the association with infection is becoming clearer," he said. Based on his analysis, Alvarez agreed that"the risks go up in patients who have been treated for the longest and those with higher levels of disability," he said.

We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:

Medscape /  🏆 386. in US

Multiple Sclerosis MS MS - Multiple Sclerosis Hypogammaglobulinemia Monoclonal Antibody Cetuximab Rituximab Multiple Sclerosis Risk MS Risk Multiple Sclerosis Risk Factors MS Risk Factors Risk Of Multiple Sclerosis Risk Of MS Igg Immunoglobulin G Colorado Wisconsin Biologic Therapy Biologics Antineoplastic Drug Anti-Cancer Agents Erlotinib Gefitinib Imatinib

United States Latest News, United States Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Feds charge 47 people linked to Sinaloa Cartel-linked drug trafficking network in Imperial ValleyFeds charge 47 people linked to Sinaloa Cartel-linked drug trafficking network in Imperial ValleyThe federal raids resulted in 36 arrests, including one Border Patrol agent; 11 people remain at large.
Read more »

Rashida Tlaib Speaks at Anti-Israel Conference Linked to Terror Group PFLPRashida Tlaib Speaks at Anti-Israel Conference Linked to Terror Group PFLPSource of breaking news and analysis, insightful commentary and original reporting, curated and written specifically for the new generation of independent and conservative thinkers.
Read more »

Major Report Uncovers CCP-Linked Influence Behind Left-Wing Anti-Israel Protests in U.S.Major Report Uncovers CCP-Linked Influence Behind Left-Wing Anti-Israel Protests in U.S.Source of breaking news and analysis, insightful commentary and original reporting, curated and written specifically for the new generation of independent and conservative thinkers.
Read more »

Chinese Communist Party-linked network behind 'well-funded' anti-Israel campus protests, group saysChinese Communist Party-linked network behind 'well-funded' anti-Israel campus protests, group saysA new report indicates a political activist group linked to the Chinese Communist Party has played a crucial role in funding and organizing anti-Israel protests.
Read more »

Colorado hospitals detect 3 cases of infections linked to stem-cell treatments received in MexicoColorado hospitals detect 3 cases of infections linked to stem-cell treatments received in MexicoAll three patients detected at two Colorado hospitals remain in treatment. The infections were apparently acquired during stem-cell injections carried out at two different clinics in the Mexican bo…
Read more »

Ohio AG warns student protesters could face felony charges under little known anti-KKK lawOhio AG warns student protesters could face felony charges under little known anti-KKK lawSharp criticism has been aimed at Ohio Attorney General Dave Yost in response to a letter he sent to the state's public universities this week.
Read more »



Render Time: 2025-02-15 14:43:41