Twenty-year-old Alexei Popyrin will not play the US Open starting next month, while world number five Elina Svitolina and seventh-ranked Kiki Bertens are out of the women's draw.
, while Federer's countryman and 2016 champion Stan Warinka has also opted out because of "the health situation in New York".
The women's draw has also been hit hard, with two more players from the top 10 joining Barty on the sidelines over the weekend.World number five Elina Svitolina — who made the semi-finals of the Australian Open, Wimbledon and US Open last year — and seventh-ranked Dutchwoman Kiki Bertens are also gone.
Popyrin's withdrawal means 2012 US champion Andy Murray, who had been granted a wild card at the tournament, will now move into the main draw. The French Open, traditionally the second major of the year, starts on September 27, meaning anyone who wanted to play both would only have a two-week turnaround from hard court to clay if they reached the final.
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