Patients with celiac disease who take an angiotensin receptor blocker (ARB) may experience worse outcomes, such as iron deficiency, diarrhea, and abdominal pain.
PHILADELPHIA — Patients with celiac disease who take an angiotensin receptor blocker may experience worse outcomes, such as increased risk of iron deficiency, diarrhea, and abdominal pain , according to a study presented at the
“When we see someone with nonresponsive celiac disease, meaning persistent symptoms despite a gluten-free diet, I do think we should review their medication list, and if they’re on an ARB, we should consider a trial off those medications to see if they respond,” she said. “A primary care provider may choose other hypertensives as well.”
The analysis included 1849 patients with celiac disease, including 1460 women and 389 men, with a median age of nearly 50 years at diagnosis. While the vast majority of patients didn’t take an ARB, 120 started one before celiac disease diagnosis and 142 started one after diagnosis. “The use of angiotensin receptor blockers may be associated with worse outcomes in the setting of celiac disease, specifically persistent symptoms and possibly poor small bowel healing as evidenced by malabsorption,” Hujoel said.
Celiac Sprue Gluten-Sensitive Enteropathy Sprue Coeliac Disease Coeliac Sprue Angiotensin Ii Receptor Blockade Angiotensin Ii Receptor Antagonist Angiotensin Receptor Blockers At1-Receptor Antagonist Sartans Abdominal Pain Receptors Pain Management Abdominal Pain Hypertension Diarrhea Diarrhoea Avitaminosis A Vitamin A Deficiency Hemoglobin Hb Hemoglobin Hgb
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