Even if patients with EGFR-mutated lung cancer progress on amivantamab plus chemotherapy, there is a survival benefit over chemotherapy alone, follow-up analyses of PAPILLON and MARIPOSA-2 showed.
)–mutated advanced non–small cell lung cancer even after disease progression, follow-up analyses of two phase 3 trials suggested.
Felip also revealed that patients receiving the frontline combination had a longer time to treatment discontinuation than those receiving chemotherapy alone and had a longer time to initiating a subsequent therapy . Antonio Passaro, MD, PhD, Division of Thoracic Oncology, European Institute of Oncology IRCCS, Milan, Italy, who was not involved in PAPILLON, called the results "very, very impressive," considering the treatment setting.
In the current analysis, the time to treatment discontinuation was significantly longer with the combination , as was the time to subsequent therapy , Gentzler reported.In both arms, 63% of patients with disease progression and treatment discontinuation received a subsequent therapy. Among 421 patients who received one or more doses of amivantamab, 49% had a dose interruption within the first 4 months. The interruption had no impact on progression-free survival or other outcomes.
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