Having a mother with Alzheimer’s could lead to a higher risk of inherited disease than a paternal history, according to a recent study from Mass General Brigham. Researchers and doctors explain.
Having a mother with Alzheimer’s could lead to a higher risk of inherited disease than a paternal history. That’s according to a recent study from Mass General Brigham. Researchers analyzed 4,400 adults between ages 65 and 85 who did not have any signs of cognitive decline, but did have amyloid show up in brain-imaging scans. The people with the higher amounts of amyloid were more likely to have mothers with symptoms of Alzheimer’s — primarily memory loss, the researchers found.
Amyloid, a protein that builds up in the brain and forms plaques that affect cognitive function, is one of the hallmarks of Alzheimer’s disease . The findings were published in JAMA Neurology in June. 'Our study showed a striking asymmetry in the impact of maternal versus paternal history of dementia on the risk of offsprings’ brain amyloid-beta protein accumulation, with maternal history having a greater impact,' senior corresponding author Hyun-Sik Yang, M.D.
Additionally, the generally longer lifespan of women compared to men may contribute to the higher observed prevalence of cognitive impairment among women,' Kloske added. Yang also spoke to this limitation, adding that the study participants were older adults and that the average life expectancy was shorter in their parents’ generation, especially for males.
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