Aggressive aging linked to antibody buildup inside body, surprising study finds

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Aggressive aging linked to antibody buildup inside body, surprising study finds
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Interestingly, reducing IgG levels in mice was found to mitigate aging effects across multiple tissues.

As we age, our bodies undergo a series of changes. While some are visible, others occur at the cellular level. Immunoglobulin G is a key antibody that helps our immune system fight off infections. However, this new study suggests that excessive IgG can contribute to cellular aging and chronic inflammation.

The study team included researchers from the Chinese Academy of Sciences, BGI Research, Capital Medical University in Beijing, several hospitals around China, and Altos Labs San Diego Institute of Science in the US. Our bodies defend against pathogens by producing protective proteins called immunoglobulins, or antibodies. IgG, the most prevalent antibody in our bloodstream, can neutralize toxins, viruses, and bacteria.The researchers examined nine tissues from male mice at different life stages.

This buildup can trigger a chain reaction, leading to cellular senescence, where cells stop dividing and start releasing inflammatory substances.The study revealed that IgG levels escalated with age in both male and female mice, as well as in human tissues.

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