The AmerGastroAssn has released a new clinical practice guideline defining the role of biomarkers in monitoring and managing ulcerativecolitis. GastroTwitter
The American Gastroenterological Association has released a new clinical practice guideline defining the role of biomarkers in monitoring and managing ulcerative colitis .
"The key take-home message is that the routine measurement of noninvasive biomarkers in addition to assessment of patient reported symptoms is critical in evaluating the disease burden of UC," said , MPH, director of clinical and translational research at NYU Langone Health's Inflammatory Bowel Disease Center, New York.
The guideline suggests that the two fecal biomarkers"may be optimal for monitoring and may be particularly useful in patients where biomarkers have historically correlated with endoscopic disease activity." In contrast, normal CRP may be insufficient to rule out moderate to severe endoscopic inflammation in patients who recently entered remission following treatment adjustment.
For patients with mild symptoms, endoscopy is generally recommended, according to the guideline, unless the patient recently had moderate to severe symptoms and has improved after treatment adjustment; in that case, biomarkers can be used to fine-tune therapy without the need for endoscopy.
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