Diabetes drugs that also promote weight loss such as Novo Nordisk’s Ozempic, becoming a darling of celebrities and investors, are being studied to tackle some of the most difficult-to-treat brain disorders, including Alzheimer’s disease.
that removing sticky amyloid plaques accumulated in the brain can slow cognition decline caused by the fatal mind-wasting disease.
She said she has since been approached by pharmaceutical companies at an increasing pace, and is currently running an Alzheimer’s trial evaluating intranasal insulin in combination with another diabetes drug. Unlike older off-patent medicines like metformin, there is commercial incentive to test newer treatments such as GLP-1 agonists, a rapidly expanding class now dominated by Ozempic, known chemically as semaglutide, and Lilly's Mounjaro, withFour companies with GLP-1 drugs, including two larger drugmakers, say they are watching for results of trials testing Novo's drug in Alzheimer's.
Despite their potential against Alzheimer's, early research has yielded mixed results, cautioned Hannah Churchill, research communications manager at the Alzheimer's Society. Parkinson's trials tend to take less time and may require fewer patients because it's easier to assess the impact on motor function characteristics of the disease to understand whether the treatments benefit the brain.
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