Country-scale genome sequencing projects are producing “the largest datasets on the planet,” Spiral Genetics CEO Adina Mangubat says. Spiral’s goal is to make sense of them.
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DNA sequencing was still very expensive and rare at the time, but Mangubat and her cofounders at Spiral Genetics anticipated a day when the cost of sequencing a genome would drop enough to allow scientists to sequence hundreds of thousands or millions of human genomes, whole populations, and compare them to learn about disease. To analyze such a volume of data, with the technology of the time, would have been prohibitively difficult and time-consuming, Mangubat predicted.
But a year after the acquisition, Mangubat says she felt the focus of the company shift from the population-level analysis she had in mind when she founded the company to the clinical market of analyzing individual patient genomes. Now, Mangubat is relaunching Spiral as a separate company focused on comparing the whole genome data of large populations after taking it through Y Combinator’s latest accelerator session.
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