Researchers found that while newer technology did not substantially reduce the risk of false positives, the chances were much lower when screening was done every 2 years - via healthing_ca healthing health canada
While breast cancer screening is a vital tool in efforts to reduce deaths from the prevalent disease, false positives are a common occurrence. When abnormalities are detected following a test, a patient is called back for additional imaging. If they are found to be cancer-free after further testing — and remain so over the course of the following year — the result is considered to be a false positive.
“To detect breast cancer early, we need to be careful and investigate any potentially abnormal findings,” said Thao-Quyen Ho, co-first author on the study and a radiologist at the University Medical Center in Ho Chi Minh, Vietnam. “So, women should not be worried if recalled for additional imaging or biopsy. The vast majority of these results are found to be benign.”
To determine the prevalence of false positives, the team analyzed data from three million screening mammograms for 903,495 women aged 40-to 79-years-old collected by the. Over 10 years of annual 3D mammography screening, they estimated that 50 per cent of women will experience at least one false positive recall; 17 per cent will receive a false positive short-interval follow-up recommendation; and 11 per cent will be subject to a false positive biopsy recommendation.
Regardless of whether 2D or 3D technology is used, false positives were considerably lower for older age groups and in women with fatty versus dense breasts. Getting screened every other year considerably lowered the probability of a false positive. “We were surprised that the newer 3D technology in breast cancer screening does not substantially reduce the risk of having a false positive result after 10 years of screening,” Ho said. “However, the chances of false positives are much lower with repeated biennial vs. annual screening.”
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