Advancements in understanding and treating breast cancer BreastCancer Cancer Research Oncology AucklandUni WEHI_research UniMelb
By Neha MathurMar 26 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Cell, researchers describe recent advancements in breast cancer research and how these findings have improved the precise diagnosis of tumor subtypes and contributed to the discovery of novel drug targets for future therapeutics.
In addition to these factors, breast cancers may vary in their genomic composition, pathology, and tumor microenvironment , collectively contributing to how these cancers respond to different therapies. Despite the known impact of these factors on therapeutic responses, most breast cancers are characterized according to their tumor size, grade, nodal involvement, and marker expression.
TNBCs follow an aggressive clinical course associated with poor prognosis. Individuals with TNBCs are also susceptible to early relapse and metastasis, particularly to the brain and lungs, thereby increasing their risk of cancer-related death. Current treatments Various sequencing approaches have been incorporated into the diagnosis process to identify breast cancer subtypes and the most effective therapies for these patients. Phenotyping, for example, can allow researchers to identify new biomarkers such as Ki67, PD-L1, and TIL score, whereas genomic assays, many of which are RNA-based, are particularly useful for identifying patients with luminal tumors to determine their chemotherapy requirements.
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