Admixture has obscured signals of historical hard sweeps in humans - Nature Ecology & Evolution

Ancient genomes reveal hidden history of human adaptation uniofadelaide NatureEcoEvo

and also as a potential source of selection artefacts owing to high levels of local genetic variation hindering read alignment across this region. However, nearly all SNPs in the MHC-III sweep region were found to lie in regions of high mappability, consistent with levels observed in the other 56 sweeps , indicating that poor read alignment was not a problem for our sweeps in general.

, The estimated nucleotide diversity across the MHC-III region of the Anatolian EF and expected diversity under a hard sweep model relative to the underlying recombination rate in cM Mb. The two dashed red lines indicate local recombination hotspots that flank the sweep region. The close correspondence between the expected and observed genetic diversity across this region is unlikely to be a bioinformatic artefact and points to the authenticity of the signal.

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