Analysis from a phase 2 study showed potential to monitor treatment response in future trials.
VIENNA — Treatment with a novel lysophosphatidic acid receptor 1 antagonist was associated with significant changes in baseline biomarkers of disease in adults with pulmonary fibrosis , based on data from more than 300 individuals.
The primary outcome was change from baseline in percent of predicted forced vital capacity . In the original study, treatment with admilparant vs placebo significantly reduced the rate of ppFVC decline over 26 weeks in both patients with IPF and PPF, with an acceptable safety profile, Maher said in his presentation.
"Specifically, it is important to evaluate the impact of therapies that block lysophosphatidic acid receptor 1 and their potential to address the altered fibrotic processes in pulmonary fibrosis," said Charles, who was not among the authors on the current study."The findings of this analysis provide insight into admilparant's mechanism of action across diverse forms of pulmonary fibrosis," he said.
"In addition, there is a lack of available validated biomarkers to monitor treatment response and disease progression," he said. "I was pleasantly surprised to see a consistent signal of effective LPA1 pathway antagonism by admilparant that may correlate with the reduced FVC decline at 26 weeks," Nambiar said.
IPF Idiopathic Pulmonary Fibrosis (IPF) IPF - Pulmonary Fibrosis Lung Fibrosis Pulmonary Fibrosis Biomarker Biological Marker Multi-Biomarker Disease Activity MBDA Multibiomarker Disease Activity Lung Receptors Blood Quality Of Life QOL Health Related Quality Of Life Health-Related Quality Of Life HRQOL Healthcare And Medical Technology
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