An accelerated schedule of intermittent theta burst stimulation proved effective in relieving depression in adults with refractory bipolar depression, results of a small sham-controlled trial showed.
An accelerated schedule of intermittent theta burst transcranial magnetic stimulation completed in less than a week is effective for treatment-resistant bipolar depression , the results of a small randomized controlled trial showed.
The investigators assessed the effectiveness of aiTBS in 12 men and 12 women with treatment-resistant bipolar disorder. All participants were on mood stabilizers for at least 4 weeks and had Montgomery-Åsberg Depression Rating Scale scores of ≥ 20. In the active treatment group, MADRS scores dropped from a mean of 30.4 at baseline to 10.5 after treatment. In contrast, the sham group experienced a minor change in MADRS scores, which decreased from a mean of 28.0 at baseline to 25.3 posttreatment.
The researchers noted that the"large effect size" of active aiTBS could be due to several factors, including optimized stimulation targeting, accelerated time course, and high pulse number . Williams noted that the stimulation and targeting approach used in the current study"mirrors most aspects of the SAINT protocol with very similar results."
Bipolar Mania Manic Depression Bipolar Affective Disorder Depression Bipolar Depression Bipolar Disorder - Depression Major Depression Major Depressive Disorder Unipolar Depression Clinical Depression MDD Brain Stimulation Brain Antidepressant Antidepressant Drug Mania Manic Refractory Remission Adverse Effects Side Effects Board Certification Boards
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