Mathematicians have uncovered a universal explanatory framework that provides a 'window into evolution.' This framework explains how molecules interact with each other in adapting to changing conditions while still maintaining tight control over essential properties that are crucial for survival.
Researchers have recently discovered fundamental molecular-level design principles that help maintain important molecules within narrow concentration ranges in biological systems, contributing to robustness and survival. This ground-breaking research provides a universal framework for understanding robust perfect adaptation and could lead to fresh approaches in tackling personalized medicine challenges like cancer drug resistance, addiction, and autoimmune diseases.
“Until now, no one had a general way to explain how this vital process was orchestrated at the molecular level through the vast, complex, often highly intricate networks of chemical reactions among different types of molecules, mostly proteins. We have now solved this problem, having discovered fundamental molecular-level design principles that organize all forms of biological complexity into robustness-promoting, and ultimately, survival-promoting, chemical reaction structures.
“However, signaling networks in nature are vastly different, having evolved to rely on the physical interactions between discrete molecules. So, nature’s ‘solutions’ operate through remarkable and highly intricate collections of interactions, without engineering’s specially designed, integral-computing components, and often without feedback loops.
Professor Liotta said the quest to uncover the fundamental design principles of biological systems throughout nature is considered to be one of the most important and far-reaching grand challenges in the life sciences.
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