People with suppressed HIV and the M184V/I viral mutation who switch medications to B/F/TAF appear to maintain viral suppression, reports an industry-sponsored analysis. HIVtreatment MedTwitter
appear to maintain viral suppression, reports an industry-sponsored analysis.
White and her colleagues analyzed pooled data from 2286 adult and 100 child participants in six randomized clinical trials investigating the safety and efficacy of switching to B/F/TAF in virologically suppressed people with HIV. At screening, participants were on three-drug antiretroviral regimens.
The researchers assessed preexisting drug resistance by historical genotypes, baseline proviral DNA genotyping, or both, and they determined virologic outcomes by last available on-treatment HIV-1 RNA. They used stepwise selection in a multivariate logistic regression model to identify potential risk factors for M184V/I.
Clinicians may comfortably switch patients to this regimen without fear of virologic failure, she added.
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