A possible link between aggregation of SARS-CoV-2 proteins and protein misfolding diseases Protein SARS SARSCoV2 Coronavirus Disease COVID NatureComms iit__mandi Cambridge_Uni CSIR_IMTECH
By Suchandrima BhowmikFeb 21 2023Reviewed by Danielle Ellis, B.Sc. The COVID-19 pandemic brought about by the severe acute respiratory syndrome coronavirus 2 led to the disruption of the global economy and the loss of human lives. Studies are still undergoing to understand the molecular mechanisms of SARS-CoV-2 pathogenesis to identify targets for therapeutic interventions. Previous research has highlighted extensive protein misfolding and aggregation associated with COVID-19.
Study: Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. Image Credit: Design_Cells / Shutterstock a The SARS-CoV-2 viral particle comprises of positive-sense single-stranded RNA, which is associated with the nucleocapsid protein , and three surface proteins, spike , membrane , and envelope , embedded in the lipid bilayer. b The ~30 kbp long genome of SARS-CoV-2 encodes for four structural, nine accessory, and sixteen non-structural proteins .
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