'With its ability to address three different pathogens, this vaccine has the potential to revolutionize the way we approach invasive fungal infections.'
The new vaccine, if clinically approved, could provide a much-needed solution to this growing problem and help prevent the spread of these infections.Fungal infections are a major public health problem that results in a significant number of deaths each year. According to estimates, these infections cause over 1.5 million deaths worldwide every year and result in billions of dollars in economic costs.
A previous study by the University of Georgia found that fungal infections also double the cost of hospitalization. Despite the significant impact of fungal infections, there are currently no effective vaccines available to protect vulnerable patients from these infections. This highlights the urgent need for a safe and effective vaccine to address this growing public health problem.
"There is a pressing need for both prevention and treatment solutions for fungal infections, especially among individuals with weakened immune systems," said , the new study's lead researcher and a professor at the College of Veterinary Medicine. "The number of patients at risk for invasive fungal infections has risen significantly in recent years."The newly developed vaccine targets the three most prevalent fungal pathogens responsible for most fatal fungal infections. In the study, the vaccine's efficacy was evaluated in four preclinical animal models, including non-human primates.
"With its ability to address three different pathogens, this vaccine has the potential to revolutionize the way we approach invasive fungal infections," Norris, who is also a faculty member of the university's Center for Vaccines and Immunology, stated. "Plans are underway to proceed with a Phase I safety trial for human use.", a researcher in infectious diseases from the University of Sydney, collaborated with the WHO to create the Fungal Priority Pathogen list in 2022.
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