Scientists at Stanford University have identified a new subtype of depression that could affect as many as a quarter of all patients with major depressive disorder (MDD).
In a randomizedinvolving over 700 adults, Stanford researchers – with a colleague from the University of Sydney in Australia – found that 27 percent of MDD patients performed worse on cognitive tasks. They also had a worse response to standard drug treatments.
"For a substantial minority of depressed patients, it is necessary to improve cognition in order to improve overall depressed mood and function," theyAccording to the authors, this is the first"clinically actionable cognitive biotype of depression" that has been found, and their findings suggest a loss in brain power isn't always a consequence of depression. It could also be a driver of it.
During the task, MDD patients with slower information processing, worse sleep problems, and poorer response inhibition tended to show reduced activation in their prefrontal cortex and cerebral cortex., as these parts of the brain are highly involved in executive functions like planning ahead, meeting goals, and sustained attention.algorithms found that the extent of a patient's cognitive impairment was linked to the extent of their depression symptoms and their improvement after treatment.
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