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However, this positioning implied that the trigeminal ganglion was not exposed to the cerebral spinal fluid that bathes the brain and spinal cord.
The fluid rapidly entered the root of the trigeminal ganglion, which further dissections showed lacks a tightly wrapped sheath that bars dissolved molecules from penetrating the trigeminal nerves any further along their spindly bodies. Rasmussen and colleagues also found the contents of the animals' CSF were altered after an aura; it contained CGRP and other molecules released from the cortex after a wave of abnormal brain activity passed through, with those molecules activating trigeminal ganglion nerves.
. However,"we also found that CSF composition quickly normalizes, suggesting that other processes might drive headache at later phases."
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