The new high-risk subtype of pediatric liver cancer was discovered using molecular profiling Up until recently, almost all pediatric liver cancers were classified as either hepatoblastoma or hepatocellular carcinoma. However, pediatric pathologists have noted that certain liver tumors have histolog
The newly identified tumors, referred to as hepatoblastomas with hepatocellular carcinoma features, often resisted conventional treatment and had dismal prognoses in the absence of more aggressive surgical procedures.Up until recently, almost all pediatric liver cancers were classified as either hepatoblastoma or hepatocellular carcinoma.
The scientists examined the tumors’ molecular profiles, which included their gene expression and genetic makeup. The researchers discovered that these molecular profiles do not fall within the hepatoblastoma or hepatocellular carcinoma classifications. These tumors, however, had recurrent molecular characteristics that have been reported in both HBs and HCCs. These tumors were classified as hepatoblastomas with hepatocellular carcinoma features .