Two clinical trials found that the nonhormonal drug elinzanetant eased hot flashes and improved sleep, two common menopause symptoms.
A new treatment for hot flashes brought relief and a better night’s rest for women experiencing these disruptive symptoms during menopause.
After the first 12 weeks, the trials switched placebo users to the drug. Studies of treatments for hot flashes often show a placebo effect, says JoAnn Pinkerton, a gynecologist specializing in menopause at the University of Virginia Health System in Charlottesville. This could be due in part to the therapeutic rituals of the trials, researchers have proposed.
In the transition to menopause, which signals the end of ovulation and menstrual periods, the ovaries’ production of the sex hormones estrogen and progesterone fluctuates and eventually stops. During the lead-up to menopause and for years after, people can experience a range of burdensome symptoms, including hot flashes, night sweats, disturbed sleep, changes in mood, loss of concentration, vaginal dryness and urgency with urination.
There is a need for nonhormonal treatments, too. For women older than 60 or those more than 10 years out from menopause, hormone therapy is tied to a higher risk of coronary heart disease, stroke and blood clots. People who’ve had estrogen-sensitive breast cancer, prior blood clots, a history of stroke, severe endometriosis and migraines with aura are among those who wouldn’t be good candidates for hormone therapy, Pinkerton says.
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