Molecular atlas of spider silk production could help bring unparalleled material to market NatureComms
. Our work provides biological evidence of this role of the silk gland and further demonstrates high convergence of several molecular functions in the spider Ma gland Duct and the silkworm ASG, including calcium ion binding, chitin binding, signal transduction, andexpression. Such overlaps were silk gland-specific and not identified in other tissue types . Furthermore, we identified convergent silk components in spider and silkworm silks, including two proteins and two major metabolites .
In conclusion, our current work comprehensively illustrates the biological basis of dragline silk formation in an orb-weaving spider. To our knowledge, this study is the first to reveal the biological mechanism of silk spinning in spiders in such detail.
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