Conventional manufacturing methods such as soft lithography and hot embossing processes can be used to bioengineer microfluidic chips, albeit with limitations, including difficulty in preparing multilayered structures, cost- and labor-consuming fabrication processes as well as low productivity.
3D bioprinting has attracted increasing attention to innovatively design and manufacture customized structures at the microscale. Materials scientists have used digital light processing for layer-by-layer vat photopolymerization to microfabricate with resolutions up to tens of microns withIn this work, Luo and colleagues developed a new digital light processing method for high-resolution and scale-up fabrication of microfluidic devices by dosing and zoning vat polymerization.
The team studied the printing quality of the new approach by comparing it with the conventional method. While the conventional method led to poor fidelity of channels due to the accumulation of excessive UV exposure, the new method contrastingly offered microchannels with significantly improved printing fidelity to allow the development of smoother internal surfaces within the microchannels with significant impact on liquid manipulation.
Luo and colleagues next investigated the mechanical stability of the microfluidic devices engineered with the new DZC-VPP method and again compared it with the conventional process. While mechanical stability is crucial for the microfluidic chips to tolerate high liquid pressure, the two materials demonstrated similar stress-strain curves.
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