A Man’s Rapid Weight Loss From Obesity Drug Led to Heart Problems

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A Man’s Rapid Weight Loss From Obesity Drug Led to Heart Problems
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A case report highlights the danger of mixing certain medications with the newest generation of weight-loss drugs.

A 62-year-old man ended up in the emergency room with hand tremors and heart palpitations six months after he began taking the weight-loss drug tirzepatide, also known as Zepbound. According to his doctors, the man’s heart predicament was likely caused by an overdose of his thyroid medication that wasn’t adjusted properly following his rapid weight loss from tirzepatide.medication, a class of drugs that mimics gut and brain hormones important to regulating hunger and metabolism.

Unfortunately, the dosage of levothyroxine needed to mimic a healthy thyroid can be affected by lots of things, including body weight. And the man’s weight loss meant that he was now taking too much levothyroxine. His atrial fibrillation and resulting symptoms were officially determined to be caused by an overflow of thyroid hormones in “the context of rapid weight loss from tirzepatide.” Thankfully, he received immediate treatment for his condition in the emergency department.

Other research has generally found that incretin drugs may have even more health benefits than currently thought. A study this Februarythat it could be used to treat sleep apnea. But the man’s doctors say this case should provide a “teachable moment”—the lesson being that every drug, no matter how useful, can have risks that should be proactively monitored by clinicians.

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