CAR T-cell therapy and related therapies that harness immune cells are getting closer to a 'cure' for some cancers, clinicians say.
. Still, it’s not impossible for a person’s cancer to come back after such a long time, Rosenberg says.
“It’s a living drug,” Rosenberg says. “They can survive in the body for years, and they appear to be able to mediate complete, durable [remissions].” The cells that stuck around weren’t the so-called “killer” T-cells that attack diseased cells, but ratherthat are typically involved in coordinating the immune response. Laboratory experiments suggested that, intriguingly, these helper CAR T-cells retained their cell-killing ability.
“This entirely new approach of creating a drug for the patient using their own cells has resulted in these dramatic long-term responses that have returned people from being very ill to normal life and certainly is here to stay.”The results could help researchers identify CAR T-cell traits to emulate in the future.
There are several reasons for this: “It’s a hostile environment, where the tumor is trying to kill the T-cells and trying to keep the T-cells out of the tumor so they…can’t actually get in there and attack the cancer,” Maloney says. Researchers are working on strategies to make T-cells more resistant to these blocking efforts, he says.
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