Pfizer developed both a vaccine (with BioNTech_Group) and an antiviral against COVID-19 by streamlining decisions and running steps in parallel - a lightspeed approach that can be applied to other diseases. World View from Annaliesa Anderson pfizer
designed against SARS-CoV-1. Despite these advantages, many challenges loomed. The mRNA approach was unproven, and early vaccines and monoclonal antibody treatments could not account for antigenic change. In the spirit of the adage about desperate times, Pfizer took a creative approach to maximize the facilitating factors, while mitigating the challenges that remained.
For Comirnaty, Pfizer’s collaboration with BioNTech leveraged the strength of both companies to rapidly develop the vaccine: mRNA experience for BioNTech and vaccine research and development for Pfizer. For Paxlovid, Pfizer used in-house experience with protease inhibitors, as well as AI- and structure-based small-molecule design to invent a main protease inhibitor that limited the risk of causing resistance.
While existing infrastructure supported the lightspeed approach, changes in Pfizer’s governance structure promoted a clear mission and unified set of goals. The result was a purpose-driven culture that matched the urgency of the approach. Vaccine and Hospital area heads representing different functions met whenever needed to assess opportunities and drive rapid decision-making within and across lines.
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