CHIP can control life-prolonging signals like insulin receptors in the cell better alone than in pairs.
A single protein can more effectively modulate aging signals compared to a group, according to researchers from the University of Cologne.
Life-extending gene products cannot be activated because CHIP attaches to the receptor and breaks it down.The research team led by Prof. Dr. Thorsten Hoppe has now demonstrated that CHIP may also identify itself with ubiquitin, preventing the formation of its dimer. They also used“Whether CHIP works alone or as a pair depends on the state of the cell.
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