The new drug doesn't affect testosterone.
With RAR-α in their sights, the researchers started looking for a compound that would block that receptor without interfering with RAR-β or RAR-γ.
With that information in hand, they moved on to testing the likely molecules in living cells. They created genetic lines of cells that made it easy to determine if a compound was inhibiting the activity of the receptors.Md Abdullah al Noman “We want a compound that can only bind [to] and slow activity in the [RAR-α] producing cell, not in the beta and gamma producing cells,” he says.The researchers finished this phase of their research with a mating study. “Male mice were given the drug every day, and they were together with female mice,” Georg says.
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