Clustering of multiple diagnostic tests in a 6-month period showed high accuracy in identifying rapid progression of glaucoma earlier than annual testing and before significant vision loss can occur.
Receive email when new articles are published onA diagnostic approach that clusters multiple tests of visual field and retinal imaging in an intense 6-month period has demonstrated the potential to identify patients likely to have fast-progressing glaucoma, according to a prospective cohort study presented on March 2, 2024, at the annual meeting of the American Glaucoma Society in Huntington Beach, California.
"As you know, clinicians don't even do annual visual field tests; the average is even less than that. So by the time patients are detected as deteriorating they have lost a significant amount of visual field," he said. The clustering approach proved highly reliable, he added. During the 2-year follow-up period, 35 eyes progressed, 25 of which progressed during the 6-month cluster period, demonstrating a sensitivity of 71% at 6 months. Through the follow-up, patients had 17 tests on average. When that analysis was reversed, 30 eyes progressed during the 6-month cluster period, 27 of which progressed during the 2-year follow-up, for a specificity of 90%.
Sasan Moghimi, MD, a glaucoma specialist and professor at Shiley Eye Institute at the University of California, San Diego, called clustering test results "an innovative strategy" for detecting rapid glaucoma progression early.
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