5 things we know and still don't know about COVID, 5 years after it appeared

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5 things we know and still don't know about COVID, 5 years after it appeared
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Five years ago, a cluster of people in Wuhan, China, fell sick with a virus never before seen in the world.

The virus is still with us, though humanity has built up immunity through vaccinations and infectionsthat exposed deep inequities in the global health system and reshaped public opinion about how to control deadly emerging viruses.The virus is still with us, though humanity has built up immunity through vaccinations and infections. It's less deadly than it was in the pandemic's early days and it no longer tops the list of leading causes of death.

It's a difficult scientific puzzle to crack in the best of circumstances. The effort has been made even more challenging by political sniping around the virus' origins and by what international researchers say are moves by China to withhold evidence that could help.How many people died from COVID-19?

“We cannot talk about COVID in the past, since it’s still with us,” WHO director Tedros Adhanom Ghebreyesus said. Today, there’s also a more traditional vaccine made by Novavax, and some countries have tried additional options. Rollout to poorer countries was slow but the WHO estimates more than 13 billion doses of COVID-19 vaccines have been administered globally since 2021.

Scientists named these variants after Greek letters: alpha, beta, gamma, delta and omicron. Delta, which became dominant in the U.S. in June 2021, raised a lot of concerns because it was twice as likely to lead to hospitalization as the first version of the virus.“It spread very rapidly," dominating within weeks, said Dr. Wesley Long, a pathologist at Houston Methodist in Texas. “It drove a huge spike in cases compared to anything we had seen previously.

The omicron relative now dominant in the U.S. is called XEC, which accounted for 45% of variants circulating nationally in the two-week period ending Dec. 21, the CDC said. Existing COVID-19 medications and the latest vaccine booster should be effective against it, Long said, since “it’s really sort of a remixing of variants already circulating.”Millions of people remain in limbo with a sometimes disabling, often invisible, legacy of the pandemic called long COVID.

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