49ers running backs Christian McCaffrey and Jordan Mason are both headed to injured reserve.
Nick Wagoner is an NFL reporter at ESPN. Nick has covered the San Francisco 49ers and the NFL at ESPN since 2016, having previously covered the St. Louis Rams for 12 years, including three years at ESPN.
After McCaffrey departed, Mason capably filled in, much like he has all season. Mason had 13 carries for 78 yards against Buffalo, despite the ankle injury and, at one point, being evaluated and cleared for a concussion. Mason finishes his season while leading the Niners in rushing with 789 yards and three touchdowns through the team's first 12 games. McCaffrey posted 202 rushing yards and no touchdowns in his abbreviated action. Mason is set to be a restricted free agent after the season with McCaffrey under contract at a cap charge of $9.8 million for 2025.
Guerendo, a fourth-round pick out of Louisville in April, scored San Francisco's lone touchdown against the Bills and has, at times, offered promise in the run game with his home run speed. On 42 attempts, Guerendo has 246 rushing yards on the season to go with a pair of touchdowns.
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