2.5 miles of neurons: World’s most complex brain map connects structure to thought

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2.5 miles of neurons: World’s most complex brain map connects structure to thought
Brain MappingElectron MicroscopyNeuroscience
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Beyond unlocking the architecture of thought, this research may open new doors in diagnosing and treating brain-related disorders.

What began with a sliver of brain tissue no larger than a grain of sand has culminated in a scientific achievement once deemed impossible. A global team of researchers has unveiled the most intricate wiring diagram ever created of a mammalian brain.The work, led by the MICrONS Project, provides a high-resolution, 3D map of part of a mouse’s visual cortex—redefining what we know about brain structure and function.The data, totaling a staggering 1.

“It has all sorts of rules of connections that we knew from various parts of neuroscience, and within the reconstruction itself, we can test the old theories and hope to find new things that no one has ever seen before.” One of the most striking discoveries was a fresh comprehension of the functioning of inhibitory neurons.

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