Ellen Pompeo as Meredith Grey in Grey's Anatomy
Since medical drama Grey's Anatomy premiered with its first group of interns in 2005, it has been beloved by fans, and its consistent success has helped it to become one of television's longest-running shows. It was created by Shonda Rhimes, who also served as showrunner, head writer, and executive producer until 2015, and is just one of many shows that has become part of her Shondaland TV empire. Season 21 is set to premiere in September 2024.
9 "You never know the biggest day of your life is going to be the biggest." Izzie Stevens As Meredith and Derek planned their wedding in “What a Difference a Day Makes,” Izzie had hallucinations of Denny , and the search for answers led to the discovery of another tumor in her brain. Meredith and Derek decided to give up their perfect wedding to Izzie and Alex instead.
7 "If you love someone you tell them, even if you're scared it's not the right thing." Mark Sloan After the plane crash in Grey's Season 8 finale, hospital staff had largely moved on as Season 9 began. In the season's second episode, Mark's condition appeared to have improved drastically, something Richard feared was a "surge"—a burst of energy terminal patients often experienced before death, typically marked in part by the patient sharing “epiphanies.
5 "Don't let what he wants eclipse what you need. He's very dreamy, but he's not the sun. You are." Cristina Yang Before Cristina left Seattle in the Season 10 finale, she decided to dance it out with Meredith one final time. Cristina also had some final words of advice for Meredith, specifically dealing with Meredith’s relationship with Derek and their future. He wanted to move to D.C.
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