+34
Nature research paper: An atlas of healthy and injured cell states and niches in the human kidney
We thank the patients who volunteered to donate tissue primarily for research purposes despite no direct immediate benefit to their clinical care; collaborators L. J. Arend, S. M. Bagnasco, C. J. Sperrati and M.
Atta for providing samples from patients with COVID-AKI; Y. Yang for his expertise in performing the in situ hybridization experiments; the members of the KPMP nomenclature working group for establishing the nephron schema and standardized nomenclature used, specifically, T. Valerius, W. Kriz, B. Kaissling and M. Rose; the members of the HuBMAP consortium including the HuBMAP HIVE for building the infrastructure for data storage and public access to reference samples, in particular, J. Silverstein, P. Kant, K. Borner and N. Gehlenborg; J. Hilton and J. Yu-Sheng Chien for building the CellxGene instance of the integrated datasets as part of the Chan Zuckerburg Initiative; the staff at the Indiana Center for Biological Microscopy for imaging assistance; the staff at the Indiana Center for Medical Genomics for sequencing of the 10x Visium samples; the staff at the Indiana Biobank for hosting the BBCI; the staff at the Kidney Translational Research Center at the Washington University and Mid America Transplant in St Louis for infrastructural support for HuBMAP samples; and the S. Steffan family for support of new omics technologies in kidney research . This publication is part of the HCA . The snCv3 and SNARE2 sequencing data were generated at the UC San Diego IGM Genomics Center supported by the National Institutes of Health and Washington University Genome Technology Access Center at the McDonnell Genome Institute partially supported by NCI Cancer Center Support to the Siteman Cancer Center and by ICTS/CTSA from the National Center for Research Resources . The KPMP data presented here were funded by the following grants from the NIDDK: U2C DK114886, UH3DK114861, UH3DK114866, UH3DK114870, UH3DK114908, UH3DK114915, UH3DK114926, UH3DK114907, UH3DK114923 and UH3DK114933. The HuBMAP data presented here were supported by OT2D033760 , U54HL145608 and U54DK134301 . Additional NIH support was provided by NIH/NIDDK K08DK107864 ; Indiana Grand Challenge Precision Health fund ; R01DK111651 ; P30 DK079312 ; P01 DK056788 ; U2CDK114886, U54DK083912, P30 DK081943/HCA: Kidney Seed Network ; K23DK125529 ; U54DK083912 ; U01MH114828 ; UH3CA246632 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.Present address: San Diego Institute of Science, Altos Labs, San Diego, CA, USA These authors contributed equally: Blue B. Lake, Rajasree Menon, Seth Winfree, Qiwen Hu, Ricardo Melo Ferreira, Kian KalhorA full list of members other than authors and their affiliations appears in the Supplementary InformationDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USADepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USADepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USAQiwen Hu, Xin Wang & Peter V. KharchenkoRicardo Melo Ferreira, Daria Barwinska, Michael Ferkowicz, James C. Williams, Yinghua Cheng, Kenneth W. Dunn, Katherine J. Kelly, Timothy A. Sutton, Michael T. Eadon, Pierre C. Dagher & Tarek M. El-AchkarEdgar A. Otto, Laura H. Mariani, Abhijit S. Naik, Sean Eddy & Matthias KretzlerAmanda Knoten, Bo Zhang, Diane Salamon, Anitha Vijayan & Sanjay JainKarol S. Balderrama, Paul J. Hoover, Evan Murray, Jamie L. Marshall, Teia Noel, Fei Chen, Anna Greka, Evan Z. Macosko & Nir HacohenSection of Nephrology, Boston University School of Medicine and Boston Medical Center, Boston, MA, USAKidney and Hypertension Unit, Joslin Diabetes Center, Boston, MA, USAHarvard Medical School, Boston, MA, USAFrancis P. WilsonPaul M. PalevskyKrzysztof Kiryluk, Paul Appelbaum, Jonathan M. Barasch, Andrew S. Bomback, Vivette D. D’Agati, Karla Mehl, Pietro A. Canetta, Ning Shang, Olivia Balderes & Satoru KudoseJohn R. Sedor, Lakeshia Bush, Agustin Gonzalez-Vicente, Jonathan Taliercio, John O’toole, Emilio Poggio, Leslie Cooperman, Stacey Jolly, Leal Herlitz, Jane Nguyen, Ellen Palmer, Dianna Sendrey & Kassandra Spates-HardenDivision of Nephrology, Johns Hopkins School of Medicine, Baltimore, MD, USADepartment of Surgery, Washington University School of Medicine, St Louis, MO, USADepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USAJeffrey B. HodginBeth Israel Deaconess Medical Center, Boston, MA, USAGearoid M. McMahon & Astrid WeinsStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, GermanyAvi RosenbergEvren U. Azeloglu, Cijang He, Ravi Iyengar, Jens Hansen & Yuguang XiongPacific Northwest National Laboratories, Richland, WA, USAPrinceton University, Princeton, NJ, USAUniversity of California, San Francisco, CA, USAGarry NolanHeather Ascani, Ulysses G. J. Balis, Chrysta Lienczewski, Becky Steck, Yougqun He, Jennifer Schaub & Victoria M. BlancRaghavan Murugan, Parmjeet Randhawa, Matthew Rosengart, Mitchell Tublin, Tina Vita, John A. Kellum, Daniel E. Hall, Michele M. Elder, James Winters & Matthew GilliamCharles E. Alpers, Kristina N. Blank, Jonas Carson, Ian H. De Boer, Ashveena L. Dighe, Jonathan Himmelfarb, Sean D. Mooney, Stuart Shankland, Kayleen Williams, Christopher Park, Frederick Dowd, Robyn L. McClelland, Stephen Daniel, Andrew N. Hoofnagle & Adam WilcoxShweta Bansal, Kumar Sharma, Manjeri Venkatachalam, Guanshi Zhang & Annapurna PamreddyVijaykumar R. Kakade, Dennis Moledina, Melissa M. Shaw, Ugochukwu Ugwuowo, Tanima Arora & Joseph Ardayfio
Scratch the next story
United States Latest News, United States Headlines
Similar News: You can also read news stories similar to this one that we have collected from other news sources.
Nightmares of Nature: Blumhouse Developing Wildlife Horror DocuseriesBlumhouse Television is developing a new docuseries titled Nightmares of Nature, centering around animals facing true-life horrors in nature.
Read more »
OBOX regulates murine zygotic genome activation and early development - NatureNature research paper: OBOX regulates murine zygotic genome activation and early development
Read more »
Balancing human and AI roles in clinical imaging - Nature MedicineNew data suggest that combining AI with human expertise could improve diagnostic accuracy while maintaining a safety net in clinical imaging. Read the News and Views from Fiona Gilbert fjg28_fiona Cambridge_Uni
Read more »
Bat biotech takes flight - Nature BiotechnologyBat biotech takes flight Harnessing the unusual biology of bats, researchers aim to turn drug discovery upside-down
Read more »
Five questions with Sanja Vicković - Nature BiotechnologyA pioneer in spatially resolved transcriptomics and genomics methods recounts her journey from professional ice hockey player to running her own lab.
Read more »